Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal-like and malignant urothelial cells.

We observed a highly significant downregulation of genes associated with the terms G2/M checkpoint and E2F targets in the Hallmark gene set and an upregulation of the interferon pathway genes, consistent with the inhibition of proliferation as discussed before (Fig. 5B ).

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