Efficacy and safety of esketamine for "treatment resistant depression": registered report for a systematic review with an individual patient data meta-analysis of randomized, double-blind, placebo-controlled trials.

BMC Med · 2025 · PMC12690855 · PMID 41310599

Europe PMC DOI

hedged sentence

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closest p

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boldest claim

The sentences

barely significantno p-value reported

highly significantno p-value reported

After our pieces drew attention to this issue, the sponsor reported a sensitivity analysis [ 14 ]: the p- value changed from highly significant to “barely significant” [ 8 ].

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