Psychedelics in Multiple Sclerosis: Mechanisms, Challenges, and Prospects for Neuroimmune Modulation and Repair.

Further supporting this, a preclinical study in Sprague Dawley rats (albeit one using a morphine-regimen model, not a demyelination model) found ibogaine administration increased gene expression and protein translation of key myelin-associated proteins, myelin basic protein (MBP) and 2′,3′-cyclic nucleotide 3′-phosphodiesterase (CNPase), in the rodent brain, with protein upregulation becoming highly significant 72 h post-administration [ 53 ].

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