CRISPR Disruption of scaRNA1 Reduces Pseudouridylation in Spliceosomal RNA U2 at U89 and Perturbs the Transcriptome in HEK293T Cells.

Gene ontology (GO) enrichment analysis displayed a highly significant over-representation of the “RNA-binding” molecular function category (GO:0003723), with an enrichment score of 147.76, p = 6.77 × 10 −65 , and FDR step up = 1.47 × 10 −60 for 6A1, and an enrichment score of 98.44, p = 1.77 × 10 −43 , and FDR step up = 3.84 × 10 −39 for clone 3B2 ( Figure 6 ).

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