Histone Deacetylase Inhibition Enhances AQP3 Levels in Human Corneal Epithelial Cells and Corneal Wound Healing in Normoglycemic and Diabetic Male Mice.

Acute hyperglycemic conditions had no effect on the expression of the damage-associated molecular pattern high-mobility group box 1 (HMGB1) or the inflammatory molecule interleukin (IL)-6; however, the high-glucose medium significantly increased the mRNA levels of the pro-inflammatory mediator IL-1β while IL-1α displayed an increasing trend ( Figure 2 ).

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