Causal Relationships Between Neuropathic Pain and Alzheimer's Disease: A Multi-Omics Mendelian Randomization Study with Exploratory Evidence of a Potential Protective Role of Diabetic Neuropathy.

J Pain Res · 2025 · PMC12691660 · PMID 41383962

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marginally significantno p-value reported

In reverse MR analysis, with AD considered as exposure and NP as outcome, we observed a marginally significant association between AD and sciatica (OR = 0.97, 95% CI: 0.95~1.00; P MR-Egger = 0.1353, P weighted median = 0.2881, P IVW = 0.0178, P simple mode = 0.4104, P weighted mode = 0.1224), suggesting a potentially weak protective effect.

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