highly significantp < 0.01
Regarding physicochemical parameters ( Supplementary Figure S2 ), temperature was negatively correlated with most genes, showing highly significant correlations with tetG , sul2 , aac(6′)-Ib-cr , and intI2 ( p < 0.01). pH correlated negatively with sul2 ( p < 0.01) and positively with tetW ( p < 0.05).