The effects of 12 weeks of chiropractic spinal adjustments on physiological biomarkers in adults: A pragmatic randomized controlled trial.

PLoS One · 2025 · PMC12697962 · PMID 41379843

Europe PMC DOI

hedged sentence

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

failed to reach significancep = 0.059so close (0.05 < p ≤ 0.1)

Blood BDNF concentration There was a significant effect of Group for BDNF levels (Chiro>Sham) at 12 weeks (mean difference = 150 ± 60; 95% CI: 40–270; p = 0.009), but this effect failed to reach significance at 16 weeks (120 ± 60; 95% CI: 0–250; p = 0.059).

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