Balanophora polysaccharide improves renal injury and fibrosis in db/db diabetic nephropathy mice via NLRP3 inflammasome mediated inflammation.

However, after BPS treatment, compared with the Model group, the co-localization of NLRP3 and Collagen IV in renal tissues of db/db mice in the BPSL 40 mg/kg group and BPSH 80 mg/kg group showed a decreasing trend, and the expression of NLRP3 and Collagen IV was decreased, suggesting a possible correlation between the NLRP3 inflammasome and Collagen IV ( Figures 5A–C ).

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