Stimulated thyroid hormone synthesis machinery drives thyrocyte cell death independent of ER stress.

Thus, whereas no 2 of the 3-component iodination system was sufficient to trigger enhanced cytotoxicity, iodination conditions yielded a highly significant level of thyroid cell death that was essentially completely blocked by 100 μM PTU ( Figure 6 ), which is a condition that blocked iodination ( Supplemental Figure 7 , lanes 1+2) and has been reported to block peroxidase-mediated death of human thyrocytes ( 41 ).

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