Asymmetric Synthesis of Quaternary Hydantoins via a Palladium-Catalyzed Aza-Heck Cyclization.

J Am Chem Soc · 2025 · PMC12703750 · PMID 41236499

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highly significantno p-value reported

This was true in all cases examined. This is highly significant, as the lack of enantioenrichment of 26 precludes it being an intermediate in route to enantioenriched 5 (via N–OPh bond reduction) and is further evidence for the aza-Heck cyclization being distinct from aza-Wacker pathways.

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