A pilot safety and tolerability study of scanning ultrasound as a neuromodulation therapy in Alzheimer's disease.

3 , 5 Upon applying SUS +MB to amyloid-depositing APP23 mice, we achieved highly significant clearance of amyloid-β pathology and improved memory functions in three spatial memory tasks. 6 Other groups similarly achieved amyloid-β clearance and functional improvements using this strategy. 7 , 8 A question that arises is whether cognitive deficits can be restored without lowering amyloid-β levels. 9 We previously addressed this question by treating senescent wild-type mice.

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