highly significantP <1×10 −14
These contrasting trajectories were supported by statistical analyses: in cluster 1, differences between batches emerged as early as 2 hpi and remained highly significant thereafter ( P <1×10 −14 at 24 hpi); in cluster 2, divergence became significant from 8 hpi onward, with very big differences at 18 hpi and 24 hpi ( P <1×10 −10 and P <1×10 −65 , respectively); and in cluster 3, batches remained comparable until a pronounced difference appeared at 24 hpi ( P <1×10 −10 ) ( Fig. 4 ).