Genetic and epigenetic insights into systemic lupus erythematosus: linking long non-coding RNA growth arrest-specific transcript 5 and interferon signature.

While our cohort was adequate to detect the primary outcomes, as evidenced by the highly significant differences in IFIT1 expression (p<0.001) and IFN signature score (p<0.001) between SLE patients and controls that reflects meaningful effect sizes, the small sample size may restrict statistical power to detect smaller effect sizes and associations, particularly for less common clinical manifestations and subgroup analysis.

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