These findings may be significant for NSCLC treatment as RNF123 was shown to suppress NSCLC proliferation and cellular activity in A549 and H1975 NSCLC cell lines, potentially emerging as a new target for treatment.
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Tanshinone IIA targets RNF123 to inhibit non-small cell lung cancer cell proliferation, migration and invasion via KAT2B-mediated H3K18ac modification.
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