Among the top-ranked genes prioritized by DENetwork, there is a highly significant enrichment of downregulated DE genes identified by DESeq2 (hypergeometric enrichment ; Fig. 3B , left), including Arrdc3, Nt5e, C1qa, Cd36, Cdkn2a, Itgam , and Ccnd1 .
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DENetwork unveils non-differentially expressed genes with functional relevance across conditions through information flow perturbation.
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