Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

Hum Hered · 2025 · PMC12711242 · PMID 41363690

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highly significantno p-value reported

However for MC4R , there are highly significant effects of LOF variants in both males and females but while males also show a large, highly significant effect of variants designated probably damaging by PolyPhen, this is not the case for females, where there is only a small estimated effect which is not statistically significant.

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