Neuron-specific homologous coding genes and non-coding regulatory regions are the most conserved amongst amniotes despite neuron-specific cell size diversity.

Sci Rep · 2025 · PMC12711955 · PMID 41274927

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highly significantp = 1.92 × 10 –9actually significant

As expected given the mesodermal origin of microglial cells 40 , we found highly significant associations between microglial cell-specific genes with the top 25% values of dN/dS and immune system-related GOs (χ 2 = 36.048, p = 1.92 × 10 –9 ), in agreement with previous reports of enrichment of immune system-related genes in microglial cells 41 .

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