A computational framework for optimizing mRNA vaccine delivery via AI-guided nanoparticle design and <i>in silico</i> gene expression profiling.

As shown in Table 3 , although the overlap between simulated and experimental DEGs was modest (8 shared genes, Fisher’s p = 0.0707), 62.5 % of them displayed concordant regulation direction, and the overall fold-change correlation (r = 0.22) indicated a positive trend in expression magnitude, supporting the biological plausibility of the simulated immune response.

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