Retinal Impairments in Mice Lacking Both Nxnl1 and Nxnl2 Genes.

In our previous study ( Supplementary Table S4 ), Nxnl1 − / − mice exhibited a reduction in M-cone density ( P = 0.05, n = 12) as early as 15 weeks of age, with functional deficits in photopic ERG responses emerging by 12 months ( P = 0.05, n = 5); however, both effects were observed at the margin of statistical significance. 11 This temporal disconnect suggests that the reductions in M-cone density may not immediately translate to detectable functional decline by ERG.

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Nxnl2 − / − showed a decreasing trend in scotopic response, although it was not statistically significant ( Figs. 5 L, 5 N).

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