Studies have reported an overall trend of increased colonic pH in UC patients, which may drop to 2–3. 44 Finally, various high-concentration digestive enzymes in the gastrointestinal tract have become important obstacles to destroying the structure of curcumin and hindering its effective absorption and utilization.
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The Construction Strategy of Curcumin Nanomedicine Delivery System and Its Application in the Treatment of Ulcerative Colitis.
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