Hypoxia-preconditioned bone marrow mesenchymal stem cell-derived exosomes ameliorate knee osteoarthritis by promoting cartilage regeneration and alleviating pain in rats.

Regen Ther · 2026 · PMC12718206 · PMID 41431477

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

a decreasing trendno p-value reported

When Norm-BMSCs-Exos or Hypo-BMSCs-Exos were co-cultured with IL-1β-treated chondrocytes, the fluorescence intensities of p16, p21, and p53 showed a decreasing trend—with a more pronounced reduction in the Hypo-BMSCs-Exos co-culture group.

also in 47,180 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.