Interleukin-17 receptor A drives cancer stem-like properties in colorectal cancer through STAT3 activation.

J Cancer · 2026 · PMC12719591 · PMID 41438576

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a decreasing trendno p-value reported

However, the STAT3 inhibitor, Stattic, significantly decreased SOX2 expression and showed a decreasing trend in the expression of CD133, LGR5, c-MYC, and ALDH1A1 in IL-17RA-overexpressing SW620 cells.

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an increasing trendno p-value reported

In SW480 cells overexpressing IL-17RA, there is an increasing trend in the mRNA levels of CD133, LGR5, ALDH1, and SOX2.

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