Topical application of the antimuscarinic pirenzepine increased lower limb nerve fibre density in a phase 2a study in type 2 patients with diabetes with peripheral neuropathy.

When combining both active dose groups (4 mL and 2 mL) in the PP population using MMRM analysis to analyse Total Norfolk Score, a highly significant (p < 0.001, MMRM) within patient improvement of 10.4 points over placebo was observed after 24 weeks of dosing ( Table 4 ).

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