Rituximab monotherapy versus glucocorticoid therapy for adult minimal change disease: a retrospective study on noninferiority.

During the 12-month follow-up period of the patients in the RTX group, the quantitative urinary protein and the absolute value of CD19 showed an overall decreasing trend, the serum albumin showed an increasing trend; the 24-h urinary protein level decreased from 7.08 (6.45, 8.99) g/24 h to 0.09 (0.06, 0.20)g/24 h and the absolute CD19 cell value decreased from 283.51 (213.94, 360.14)/μL to 23.71 (0.79, 103.79)/μL, whereas the serum albumin gradually increased from 19.85 (16.78, 25.38) g/L to 43.60 (38.50, 45.60) g/L ( Figure 3 ).

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The probability of the noninferiority test was one-tailed and the statistical significance was set at p <0.025, whereas the probability of the rest of the tests was two-tailed and the statistical significance was set at p <0.05, with p <0.01 indicating a highly significant difference.

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