Evaluation of the Association between Genetic Polymorphism of Interleukin-1 Beta (-511C/T and +3953C/T) and Cervical Cancer Susceptibility.

As per 2020 GLOBOCAN, it is the fourth most commonly diagnosed cancer and the leading cause of cancer death in women, with an estimated 604,127 new cases and 341,831 fatalities. 1 Epidemiological studies have demonstrated that the human papilloma virus (HPV) is officially designated as the main cause of CC, primarily HPV-16 and HPV-18. 2 HPV-16 was found to be highly significant in tissues from CC patients, followed by HPV-18. 3 According to the molecular mechanism of CC, HPV deoxyribonucleic acid (DNA) was integrated into the host's genome which prompted keratinocytes to change the uterine cervix into cancer. 4 The uterine body and vagina are connected via the cervix.

also in 132,142 other papers