Novel insight into the gene etiology of ulcerative colitis gained from transcriptome association study and single-cell sequence analysis.

The ARPC2 gene (ENSG00000163466), mapped to genomic coordinates: chr2p218,217,141–218,254,356, demonstrates a highly significant positive association with UC (β = 1.10, P = 1.53 × 10− 6 ).

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The analysis categorizes genes into 2 groups: jointly significant genes, whose results remain significant, and marginally significant genes, which become non-significant.

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