Tetrahydrocurcumin for Major Depressive Disorder with Therapeutic Potential and Mechanistic Insights from Clinical and Preclinical Studies.

Mol Neurobiol · 2025 · PMC12727745 · PMID 41432971

Europe PMC DOI

hedged sentence

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

marginally significantp = 0.053so close (0.05 < p ≤ 0.1)

However, itemized analysis revealed that THC augmentation specifically improved gastrointestinal symptoms (U = 16.00, p = 0.025) compared to ESC monotherapy, while showing marginally significant lesser improvement in psychomotor agitation (p = 0.053).

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