highly significantp < 2 x 10 ‐16
Result After controlling for baseline age, sex, education, APOE ε4 dosage, and self‐reported race, IFI44L genotype strongly associated with clinical trajectories in clinically normal (CN) individuals and those with mild cognitive impairment (MCI) in the ADNI cohort, with the rs273259 alternate (G) allele displaying a highly significant, dose‐dependent relationship with worse clinical trajectories (for CDR‐SB, in CN, p < 2 x 10 ‐16 ; in MCI, p = 1.1 x 10 ‐6 ; Figure 1A‐B).