Identification of Novel Susceptibility Genes for Early-Onset Colorectal Cancer Through Germline Rare Variant Burden Testing.

Cancers (Basel) · 2025 · PMC12731108 · PMID 41463182

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borderline significanceno p-value reported

Additional genes ( STK25 , PGBD4 , DIRAS3 , ATG3 , RPS6KA4 , and DDX42 ) demonstrated borderline significance, implicating pathways related to kinetochore assembly, autophagy regulation, and immune signaling.

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borderline significantno p-value reported

Using a Bonferroni-corrected significance threshold ( p value of 2.7 × 10 −6 ) and a borderline significant threshold ( p value of 5.5 × 10 −5 ), seven genes showed statistically significant or borderline significant associations in at least one test: MEIKIN , STK25 , PGBD4 , DIRAS3 , ATG3 , RPS6KA4 , and DDX42 .

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