Inflammatory and Neurotrophic Factors and Their Connection to Quality of Life in Progressive Supranuclear Palsy-Single-Center Study.

As in our study, there was only a trend toward significance in terms of IL-1β concentration, so we assume that enrolling a larger cohort (or multi-center data) would make the sample strong enough to achieve statistical significance in studies of that strongly pro-inflammatory cytokine.

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Conclusions Further research in neurodegenerative diseases needs to be focused on understanding the role of inflammation as a possibly significant pathogenic factor [ 33 ].

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