Therefore, in the case of HGPS, the neural crest cell nucleus might not respond properly to mechanical cues, which are highly significant in neural crest cell differentiation or migration, so that tissues would be underrepresented with neural crest-derived cells, causing the HGPS phenotype in them. 3.
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Why and How Are Infants with Hutchinson-Gilford Progeria Syndrome Born Without Severe Manifestations?
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