S-Equol as a Gut-Derived Phytoestrogen Targeting Estrogen Receptor β: A Promising Bioactive Nutrient for Bone Health in Aging Women and Men: A Narrative Review.

In a 2-year study of 89 European postmenopausal women with or at risk for osteoporosis, soymilk supplementation alone prevented lumbar spine bone loss, and a nonsignificant trend toward greater BMD gain in equol producers (+2.8%) compared with non-producers (+0.6%) [ 47 ].

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