Pharmacokinetics of CYP2C19- and CYP3A4-Metabolized Drugs in Cirrhosis Using a Whole-Body PBPK Approach.

Pharmaceutics · 2025 · PMC12737180 · PMID 41471097

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an increasing trendno p-value reported

For oral drugs (Omeprazole for example), the decrease in the value of K t resulted in delayed absorption of the drug and slowed down the rate of absorption in the intestines, with a significant backward shift of Tmax and an increasing trend in the plasma concentration of the drug. 3.7.

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