Prognostic and therapeutic response prediction in glioblastoma multiforme using a lactylation-associated gene signature.

Discov Oncol · 2025 · PMC12748479 · PMID 41296151

Europe PMC DOI

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closest p · 0.0× alpha

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highly significantp < 0.001actually significant

After adjusting for key clinical variables including age, IDH status, and MGMT status, the LRGS remained a highly significant independent prognostic risk factor in all three CGGA cohorts (CGGA-301: HR = 2.64, p < 0.001; CGGA-693: HR = 1.66, p < 0.001; CGGA-325: HR = 2.51, p < 0.001) (Fig. 3 G-I).

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