Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype.

Aging Cell · 2026 · PMC12748510 · PMID 41466483

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highly significantno p-value reported

However, in old mice, there was a highly significant increase in TIF‐IA in the nfkb1 −/− group, compared to WT (Figure 2B ).

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