We noted a mild trend towards increase in microglia and oligodendrocyte abundance in App NL-G-F mice with increased age (Fig. 2 C), consistent with progressive amyloid pathology and expected neuroinflammatory changes.
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Epigenetic and transcriptomic alterations precede amyloidosis in the Alzheimer's disease App<sup>NL-G-F</sup> knock-in mouse model.
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