Barely Significant
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Impact of COVID-19 lockdown on methadone and buprenorphine prescriptions in England primary cares: an interrupted time series analysis.

Harm Reduct J · 2025 · PMC12750698 · PMID 41291787

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a decreasing trendno p-value reported
However, there was a decreasing trend in monthly DDDs (a 1.2% decrease each month) and dispensed items (a 0.07% decrease each month) of methadone during the COVID-19 lockdown.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.