Barely Significant
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Nutrigenomics meets multi-omics: integrating genetic, metabolic, and microbiome data for personalized nutrition strategies.

Genes Nutr · 2025 · PMC12751198 · PMID 41272493

Europe PMCDOI
1
hedged sentence
0.0080
closest p · 0.2× alpha
0.0080
boldest claim

The sentences

marginally significantP = 0.008actually significant
Clinically, these variants are associated with increased cardiovascular disease (CVD) risk; a 2023 meta-analysis of 66 studies ( n = 37,263) demonstrated that C677T carriers have a 13–20% higher odds of myocardial infarction (MI) under dominant (OR = 1.16, 95% CI:1.06–1.28, P = 0.008) and recessive (OR = 1.20, 95% CI:1.12–1.28, P < 0.001) models, with similar but marginally significant associations for A1298C (recessive OR = 1.27, 95% CI:1.06–1.51, P = 0.008), underscoring the need for genetic screening in CVD prevention [ 44 ].

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