Differential chromatin accessibility response to retinoic acid in neuroblastoma with ATRX in-frame-deletions versus ATRX loss-of-function.

Although comparisons could not be made with matched wild-type cells in these models, we noted that both cell lines showed highly significant increases in chromatin accessibility at the direct RA genes DHRS3, CYP26A and CYP26B in response to RA, alongside EXOC6B which sits adjacent to CYP26B on 2p13.2.

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In conclusion, we demonstrate differences in chromatin response to RA in neuroblastoma according to type of ATRX alteration and propose that within the ATRX subgroup, there is likely to be significant heterogeneity in response to differentiation therapies depending on the precise type of alteration.

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