Notably, while the variants identified by the logistic could appear as potential false positives since neither of them were even close to being statistically significant in other models, one (rs34962991) is associated with TMEM150B , which has relevance to estradiol metabolism since it has previously been associated with menopausal age [ 36 , 37 ].
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Improving accuracy in genome-wide association studies: a two-step approach for handling below limit of detection biomarker measurements.
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The concordance between the models was also low, and most findings were borderline significant.
The latter is emerging as an essential and highly significant aspect with the growing interest in leveraging GWAS summary statistics for deriving polygenic risk scores (PRS) and Mendelian randomization (MR), where an accurate effect estimate is crucial.