FOXO1 re-expression with a dual-recombinase allele rescues class switching in germinal center B cells.

J Exp Med · 2026 · PMC12755864 · PMID 41474973

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Strikingly, Foxo1-rescued cells showed a highly significant enrichment of FOXO1-upregulated genes compared with Foxo1-KO cells, at levels comparable to the enrichment observed for Foxo1 control cells ( Fig. 3 D , left panels), while FOXO1-downregulated genes were highly enriched in the Foxo1-KO cells ( Fig. 3 D , right panels).

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