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Puberty-Promoting Treatment and Psychosocial Well-Being in Boys With Constitutional Delay of Puberty: A Randomized Controlled Trial.

Clin Endocrinol (Oxf) · 2026 · PMC12757888 · PMID 41054004

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a small trendno p-value reported
There was a small trend towards increasing effect sizes over time.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.