Age-dependent increases in dorsal hippocampal postsynaptic α5GABA-a receptors may be lost in a rat model of Alzheimer's disease.

Using an antibody against γ2 to pull down all γ2-containing GABA A Rs (including those with α5βxγ2 subtypes), we discovered a potential, although not yet significant decrease in the total amount of hippocampal α5 subunits purified by their association with γ2.

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