highly significantp < 0.0001
3 F) demonstrate highly significant reductions in TRAF3IP2 (4IC SCR : 75 ± 1% vs. 4IC TRAF3IP2KD : 45 ± %), NAMPT (55 ± 1% vs. 10 ± %), and SIRT1 (65 ± % vs. 40 ± %); p < 0.0001.
3 F) demonstrate highly significant reductions in TRAF3IP2 (4IC SCR : 75 ± 1% vs. 4IC TRAF3IP2KD : 45 ± %), NAMPT (55 ± 1% vs. 10 ± %), and SIRT1 (65 ± % vs. 40 ± %); p < 0.0001.