Pancreatic cancer: molecular pathogenesis and emerging therapeutic strategies.

Signal Transduct Target Ther · 2026 · PMC12764932 · PMID 41484057

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highly significantno p-value reported

In conclusion, substantial evidence suggests that chronic stress has a highly significant effect on the interaction between nerves and cancer cells, primarily through activation of the SNS, driving the progression of stage 1 (localized tumor) to stage 4 (metastatic PDAC) PDAC and depressing antitumor immunity, 307 , 318 as summarized in Fig. 4 .

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