Pathway analysis of upregulated transcripts in bryostatin-treated cells compared with vehicle-treated cells showed highly significant upregulation of B-cell specific signaling mechanisms including B-cell differentiation and activation, B-cell receptor signaling, positive regulation of NF-κB signal transduction, chemokine signaling and inflammatory response pathways ( figure 5D ).
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Affinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies.
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