At the same time, relative transcriptional abundance of activated hepatic stellate cells (HSC) and macrophages reduced, CD8 T cells and natural killer cells remained unaltered, whereas cholangiocyte abundance showed an increasing trend ( figure 1 ). 18 Many of the genes that remain upregulated following a successful KPE are involved with fibrogenesis, myofibroblast activation, and cholangiocyte activation and injury modulated by TGF-β signaling including several collagen genes. 17 19 In Helsinki, protocol follow-up NL biopsies ar
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