SGSS05-NS3, a covalent SETD8 inhibitor that activates p53 pathway in neuroblastoma.

J Exp Clin Cancer Res · 2025 · PMC12766961 · PMID 41419951

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highly significantno p-value reported

SGSS05-NS3 at 3.2 μM exhibited average IC 50 at 96 h and a highly significant p-value for the In Vitro Therapeutic Index (IVTI) across the 8 NB cell lines compared with control cell lines (Figure S1A-S1C and Table S1).

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