IL-15 signaling via cis- and trans-presentation to progenitor-exhausted CD8<sup>+</sup> T cells enhances radio-immunotherapy efficacy in ESCC.

After RT, the proportion of PD-1 high CD8 + T cells showed a decreasing trend (Fig. 5 F), which mainly reflected in the decrease of PD-1 high CD8 + Tem and Tcm cells (Fig. 5 F, Figure S11A).

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After RT, there was an increasing trend in CD8 + Tcm in the spleen, while CD8 + Tem showed a decreasing trend, with these changes being more pronounced in the group receiving the combination of RT, anti-PD-1 and IL-15/IL-15RA treatment (Fig. 5 I).

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